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Literature summary for 1.8.1.6 extracted from

  • Mironov, A.; Seregina, T.; Shatalin, K.; Nagornykh, M.; Shakulov, R.; Nudler, E.
    CydDC functions as a cytoplasmic cystine reductase to sensitize Escherichia coli to oxidative stress and aminoglycosides (2020), Proc. Natl. Acad. Sci. USA, 117, 23565-23570 .
    View publication on PubMed
Search for more literature for 1.8.1.6

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Escherichia coli 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-cystine + NADH + H+ Escherichia coli
-
 2 L-cysteine + NAD+
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-cystine + NADH + H+
-
 Escherichia coli 2 L-cysteine + NAD+
-
 ?

Synonyms

Synonyms Comment Organism
CydDC
-
 Escherichia coli

General Information

General Information Comment Organism
metabolism the enzyme complex CydDC does not export L-cysteine from cytoplasm, but rather reduces cytoplasmic cystine Escherichia coli
physiological function the enzyme sensitizes Escherichia coli to oxidative (H2O2) stress and aminoglycosides Escherichia coli