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Literature summary for 1.8.1.7 extracted from

  • Zhao, Y.; Seefeldt, T.; Chen, W.; Wang, X.; Matthees, D.; Hu, Y.; Guan, X.
    Effects of glutathione reductase inhibition on cellular thiol redox state and related systems (2009), Arch. Biochem. Biophys., 485, 56-62.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.8.1.7

Inhibitors

Inhibitors Comment Organism Structure
2-acetylamino-3-[4-(2-acetylamino-2-carboxy-ethylsulfanylthio carbonylamino)phenylthiocarbamoylsulfanyl]propionic acid irreversible and selective glutathione reductase inhibitor, almost complete inhibition at 0.1 mM for 1 h, thereafter, the enzyme activity starts to return and reaches 63% of the control at the end of 8 h Chlorocebus aethiops

Organism

Organism UniProt Comment Textmining
Chlorocebus aethiops
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
CV-1 cell
-
 Chlorocebus aethiops
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione disulfide + NADPH + H+
-
 Chlorocebus aethiops glutathione + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
glutathione reductase
-
 Chlorocebus aethiops

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Chlorocebus aethiops
NADPH
-
 Chlorocebus aethiops

General Information

General Information Comment Organism
malfunction in addition to a decrease in GSH and increase in GSSG, inhibition of glutathione reductase increases the ratios of NADH/NAD+ and NADPH/NADP+. Significant protein glutathionylation is observed. However, the inhibition does not affect the formation of reactive oxygen species or expression of antioxidant defense enzyme systems (glutathione reductase, glutathione peroxidase, catalase, and superoxide dismutase) Chlorocebus aethiops