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Literature summary for 1.8.1.7 extracted from

  • Yan, J.; Ralston, M.M.; Meng, X.; Bongiovanni, K.D.; Jones, A.L.; Benndorf, R.; Nelin, L.D.; Joshua Frazier, W.; Rogers, L.K.; Smith, C.V.; Liu, Y.
    Glutathione reductase is essential for host defense against bacterial infection (2013), Free Radic. Biol. Med., 61C, 320-332.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glutathione disulfide + NADPH + H+ Mus musculus
-
 glutathione + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione disulfide + NADPH + H+
-
 Mus musculus glutathione + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
Gsr
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Mus musculus

General Information

General Information Comment Organism
malfunction enzyme-deficient mice exhibit increased morbidity and mortality but do not exhibit a greater sensitivity to lipopolysaccharide than do wild type mice. Neutrophils of enzyme-deficient mice reveal impaired phagocytosis Mus musculus
physiological function glutathione reductase is essential for host defense against bacterial (group B Streptococcus) infection. The oxidative defense mechanism mediated by the enzyme is required for an effective innate immune response against bacteria, probably by preventing phagocyte dysfunction due to oxidative damage Mus musculus