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Literature summary for 1.8.1.9 extracted from
- Protein disulfide-isomerase is a substrate for thioredoxin reductase and has thioredoxin-like activity (1990), J. Biol. Chem., 265, 9114-9120.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.035 | - |
protein disulfide-isomerase | - |
Bos taurus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Escherichia coli | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| thymus | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | - |
Escherichia coli | ? | - |
? |  |
| additional information | specific for NADPH, B side of nicotinamide ring | Bos taurus | ? | - |
? | |
| protein disulfide isomerase + NADPH | - |
Bos taurus | protein disulfide isomerase + NADP+ | protein disulfide isomerase with reduced disulfides | r | |
| protein disulfide isomerase + NADPH + H+ | - |
Bos taurus | ? | - |
r | |
| thioredoxin + NADP+ | - |
Escherichia coli | thioredoxin disulfide + NADPH | - |
r | |
| thioredoxin + NADP+ | - |
Bos taurus | thioredoxin disulfide + NADPH | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TR | - |
Escherichia coli |
| TR | - |
Bos taurus |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 500 | - |
protein disulfide-isomerase | - |
Bos taurus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Escherichia coli | |
| NADPH | - |
Bos taurus | |
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Release 2023.1 (January 2023)
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