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Literature summary for 1.8.1.9 extracted from
- The stereospecific suicide inhibition of human melanoma thioredoxin reductase by 13-cis-retinoic acid (1989), Biochem. Biophys. Res. Commun., 160, 573-579.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 13-cis-retinoic acid | - |
Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| thioredoxin + NADP+ | Homo sapiens | major anti-oxidant in keratinocytes, melanocytes, melanoma cells | thioredoxin disulfide + NADPH | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| thioredoxin + NADP+ = thioredoxin disulfide + NADPH + H+ | inhibition mechanism | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| melanoma cell | metastatic melanotic | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| thioredoxin + NADP+ | - |
Homo sapiens | thioredoxin disulfide + NADPH | - |
? | |
| thioredoxin + NADP+ | major anti-oxidant in keratinocytes, melanocytes, melanoma cells | Homo sapiens | thioredoxin disulfide + NADPH | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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