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Literature summary for 1.8.1.9 extracted from

  • Xia, L.; Nordman, T.; Olsson, J.M.; Damdimopoulos, A.; Bjorkhem-Bergman, L.; Nalvarte, I.; Eriksson, L.C.; Arner, E.S.; Spyrou, G.; Bjornstedt, M.
    The mammalian cytosolic selenoenzyme thioredoxin reductase reduces ubiquinone. A novel mechanism for defense against oxidative stress (2003), J. Biol. Chem., 278, 2141-2146.
    View publication on PubMed
Search for more literature for 1.8.1.9

Inhibitors

Inhibitors Comment Organism Structure
Zinc 0.05 mM, 50% inhibition Bos taurus

Metals/Ions

Metals/Ions Comment Organism Structure
selenium selenoprotein Homo sapiens
selenium selenoprotein Rattus norvegicus
selenium selenoprotein Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NADPH + H+ + ubiquinone-10 Homo sapiens HEK cells overexpressing TrxR1 reduce ubiquinone-10 NADP+ + ubiquinol-10
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Escherichia coli
-
-
-
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney HEK cell overeexpressing TrxR1 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme does not reduce ubiquinone-10 Escherichia coli ?
-
 ?
NADH + ubiquinone-10
-
 Homo sapiens NAD+ + ubiquinol-10
-
 ?
NADH + ubiquinone-10
-
 Rattus norvegicus NAD+ + ubiquinol-10
-
 ?
NADH + ubiquinone-10
-
 Bos taurus NAD+ + ubiquinol-10
-
 ?
NADPH + H+ + ubiquinone-10
-
 Homo sapiens NADP+ + ubiquinol-10
-
 ?
NADPH + H+ + ubiquinone-10
-
 Rattus norvegicus NADP+ + ubiquinol-10
-
 ?
NADPH + H+ + ubiquinone-10
-
 Bos taurus NADP+ + ubiquinol-10
-
 ?
NADPH + H+ + ubiquinone-10 HEK cells overexpressing TrxR1 reduce ubiquinone-10 Homo sapiens NADP+ + ubiquinol-10
-
 ?

Synonyms

Synonyms Comment Organism
TrxR1
-
 Escherichia coli
TrxR1
-
 Homo sapiens
TrxR1
-
 Rattus norvegicus
TrxR1
-
 Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
 Bos taurus

pH Range

pH Minimum pH Maximum Comment Organism
6.5 8.5 pH 6.5: about 50% of maximal activity, pH 8.5: about 60% of maximal activity Bos taurus

Cofactor

Cofactor Comment Organism Structure
NADH as active as NADPH in reduction of ubiquinone-10 Homo sapiens
NADH as active as NADPH in reduction of ubiquinone-10 Rattus norvegicus
NADH as active as NADPH in reduction of ubiquinone-10 Bos taurus
NADPH
-
 Homo sapiens
NADPH
-
 Rattus norvegicus
NADPH
-
 Bos taurus