Inhibitors | Comment | Organism | Structure |
---|---|---|---|
allyl isothiocyanate | 0.0205 mM, 50% inhibition after 30 min preincubation in assay with 5,5'-dithiobis(2-nitrobenzoic acid) as substrate | Homo sapiens | |
Benzyl isothiocyanate | 0.0033 mM, 50% inhibition after 30 min preincubation in assay with 5,5'-dithiobis(2-nitrobenzoic acid) as substrate | Homo sapiens | |
diallyl disulfide | 0.38 mM, 50% inhibition after 30 min preincubation in assay with 5,5'-dithiobis(2-nitrobenzoic acid) as substrate | Homo sapiens | |
phenethyl isothiocyanate | 0.075 mM, 50% inhibition after 30 min preincubation in assay with 5,5'-dithiobis(2-nitrobenzoic acid) as substrate | Homo sapiens | |
sulforaphane | 0.04 mM, 50% inhibition after 30 min preincubation in assay with 5,5'-dithiobis(2-nitrobenzoic acid) as substrate | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
placenta | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+ | - |
Homo sapiens | 2-nitro-5-thiobenzoate + NADP+ | - |
? | |
thioredoxin disulfide + NADPH + H+ | - |
Homo sapiens | thioredoxin + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TrxR | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0033 | - |
25°C, 30 min preincubation in assay with 5,5'-dithiobis(2-nitrobenzoic acid) as substrate | Homo sapiens | Benzyl isothiocyanate | |
0.0205 | - |
25°C, 30 min preincubation in assay with 5,5'-dithiobis(2-nitrobenzoic acid) as substrate | Homo sapiens | allyl isothiocyanate | |
0.04 | - |
25°C, 30 min preincubation in assay with 5,5'-dithiobis(2-nitrobenzoic acid) as substrate | Homo sapiens | sulforaphane | |
0.075 | - |
25°C, 30 min preincubation in assay with 5,5'-dithiobis(2-nitrobenzoic acid) as substrate | Homo sapiens | phenethyl isothiocyanate | |
0.38 | - |
25°C, 30 min preincubation in assay with 5,5'-dithiobis(2-nitrobenzoic acid) as substrate | Homo sapiens | diallyl disulfide |