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Literature summary for 1.8.1.9 extracted from

  • Stoner, C.S.; Pearson, G.D.; Koc, A.; Merwin, J.R.; Lopez, N.I.; Merrill, G.F.
    Effect of thioredoxin deletion and p53 cysteine replacement on human p53 activity in wild-type and thioredoxin reductase null yeast (2009), Biochemistry, 48, 9156-9169.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.8.1.9

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-
Saccharomyces cerevisiae W303-1A
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
thioredoxin disulfide + NADPH + H+
-
 Saccharomyces cerevisiae thioredoxin + NADP+
-
 ?
thioredoxin disulfide + NADPH + H+
-
 Saccharomyces cerevisiae W303-1A thioredoxin + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
thioredoxin reductase 1
-
 Saccharomyces cerevisiae
Trr1
-
 Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Saccharomyces cerevisiae
NADPH
-
 Saccharomyces cerevisiae

General Information

General Information Comment Organism
malfunction reporter gene transactivation by human p53 is inhibited in budding yeast lacking the TRR1 gene encoding thioredoxin reductase. Decreased reporter gene activity in thioredoxin reductase null cells is due to reduced p53 specific activity rather than reduced p53 protein levels Saccharomyces cerevisiae