Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(4-methylpyrimidine-2-thiolato-kappaS)(1,3,5-triaza-7-phosphatricyclo[3.3.1.13,7]decane-kappaP)gold | - |
Homo sapiens | |
(4-methylpyrimidine-2-thiolato-kappaS)[1,1'-(1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane-3,7-diyl-kappaP)diethanone]gold | - |
Homo sapiens | |
(pyridine-2-thiolato-kappaS)(1,3,5-triaza-7-phosphatricyclo[3.3.1.13,7]decane-kappaP)gold | - |
Homo sapiens | |
(pyridine-2-thiolato-kappaS)[1,1'-(1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane-3,7-diyl-kappaP)diethanone]gold | - |
Homo sapiens | |
(pyrimidine-2-thiolato-kappaS)(1,3,5-triaza-7-phosphatricyclo[3.3.1.13,7]decane-kappaP)gold | - |
Homo sapiens | |
auranofin | - |
Homo sapiens | |
cisplatin | - |
Homo sapiens | |
trisodium (4,5-dihydro-1,3-thiazole-2-thiolato-kappaS2)[3,3',3''-(phosphanetriyl-kappaP)tribenzenesulfonato(3-)]aurate(3-) | - |
Homo sapiens | |
trisodium [3,3',3''-(phosphanetriyl-kappaP)tribenzenesulfonato(3-)](pyrimidine-2-thiolato-kappaS)aurate(3-) | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | isoform TrxR2 | Homo sapiens | 5829 | - |
mitochondrion | isoform TrxR2 | Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-2780 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+ | - |
Homo sapiens | 2-nitro-5-thiobenzoate + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
thioredoxin reductase | - |
Homo sapiens |
TrxR1 | isoform | Homo sapiens |
TrxR2 | isoform | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Homo sapiens | |
NADPH | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00000062 | - |
isoform TrxR1, in 0.2 M Na/K phosphate buffer (pH 7.4), at 37°C | Homo sapiens | trisodium [3,3',3''-(phosphanetriyl-kappaP)tribenzenesulfonato(3-)](pyrimidine-2-thiolato-kappaS)aurate(3-) | |
0.00000074 | - |
isoform TrxR1, in 0.2 M Na/K phosphate buffer (pH 7.4), at 37°C | Homo sapiens | auranofin | |
0.00000096 | - |
isoform TrxR1, in 0.2 M Na/K phosphate buffer (pH 7.4), at 37°C | Homo sapiens | (4-methylpyrimidine-2-thiolato-kappaS)(1,3,5-triaza-7-phosphatricyclo[3.3.1.13,7]decane-kappaP)gold | |
0.00000154 | - |
isoform TrxR1, in 0.2 M Na/K phosphate buffer (pH 7.4), at 37°C | Homo sapiens | (pyridine-2-thiolato-kappaS)[1,1'-(1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane-3,7-diyl-kappaP)diethanone]gold | |
0.00000155 | - |
isoform TrxR1, in 0.2 M Na/K phosphate buffer (pH 7.4), at 37°C | Homo sapiens | (4-methylpyrimidine-2-thiolato-kappaS)[1,1'-(1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane-3,7-diyl-kappaP)diethanone]gold | |
0.00000161 | - |
isoform TrxR1, in 0.2 M Na/K phosphate buffer (pH 7.4), at 37°C | Homo sapiens | (pyridine-2-thiolato-kappaS)(1,3,5-triaza-7-phosphatricyclo[3.3.1.13,7]decane-kappaP)gold | |
0.00000167 | - |
isoform TrxR1, in 0.2 M Na/K phosphate buffer (pH 7.4), at 37°C | Homo sapiens | trisodium (4,5-dihydro-1,3-thiazole-2-thiolato-kappaS2)[3,3',3''-(phosphanetriyl-kappaP)tribenzenesulfonato(3-)]aurate(3-) | |
0.00000192 | - |
isoform TrxR1, in 0.2 M Na/K phosphate buffer (pH 7.4), at 37°C | Homo sapiens | (pyrimidine-2-thiolato-kappaS)(1,3,5-triaza-7-phosphatricyclo[3.3.1.13,7]decane-kappaP)gold | |
0.00000245 | - |
isoform TrxR2, in 0.2 M Na/K phosphate buffer (pH 7.4), at 37°C | Homo sapiens | auranofin | |
0.00000406 | - |
isoform TrxR2, in 0.2 M Na/K phosphate buffer (pH 7.4), at 37°C | Homo sapiens | (4-methylpyrimidine-2-thiolato-kappaS)(1,3,5-triaza-7-phosphatricyclo[3.3.1.13,7]decane-kappaP)gold | |
0.00000412 | - |
isoform TrxR2, in 0.2 M Na/K phosphate buffer (pH 7.4), at 37°C | Homo sapiens | (pyridine-2-thiolato-kappaS)(1,3,5-triaza-7-phosphatricyclo[3.3.1.13,7]decane-kappaP)gold | |
0.00000586 | - |
isoform TrxR2, in 0.2 M Na/K phosphate buffer (pH 7.4), at 37°C | Homo sapiens | (4-methylpyrimidine-2-thiolato-kappaS)[1,1'-(1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane-3,7-diyl-kappaP)diethanone]gold | |
0.0000062 | - |
isoform TrxR2, in 0.2 M Na/K phosphate buffer (pH 7.4), at 37°C | Homo sapiens | (pyridine-2-thiolato-kappaS)[1,1'-(1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane-3,7-diyl-kappaP)diethanone]gold | |
0.00000673 | - |
isoform TrxR2, in 0.2 M Na/K phosphate buffer (pH 7.4), at 37°C | Homo sapiens | (pyrimidine-2-thiolato-kappaS)(1,3,5-triaza-7-phosphatricyclo[3.3.1.13,7]decane-kappaP)gold | |
0.00000682 | - |
isoform TrxR2, in 0.2 M Na/K phosphate buffer (pH 7.4), at 37°C | Homo sapiens | trisodium (4,5-dihydro-1,3-thiazole-2-thiolato-kappaS2)[3,3',3''-(phosphanetriyl-kappaP)tribenzenesulfonato(3-)]aurate(3-) | |
0.00000695 | - |
isoform TrxR2, in 0.2 M Na/K phosphate buffer (pH 7.4), at 37°C | Homo sapiens | trisodium [3,3',3''-(phosphanetriyl-kappaP)tribenzenesulfonato(3-)](pyrimidine-2-thiolato-kappaS)aurate(3-) |