Literature summary for 1.8.1.B1 extracted from

Angelucci, F.; Miele, A.E.; Boumis, G.; Dimastrogiovanni, D.; Brunori, M.; Bellelli, A.
Glutathione reductase and thioredoxin reductase at the crossroad: the structure of Schistosoma mansoni thioredoxin glutathione reductase (2008), Proteins, 72, 936-945.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
crystal structure at 2.2 A resolution of TGR, deleted in the last two residues	Schistosoma mansoni

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.205	-	GSSG	-	Schistosoma mansoni
0.71	-	5,5'-dithiobis(2-nitrobenzoic acid)	-	Schistosoma mansoni

Organism

Organism	UniProt	Comment	Textmining
Schistosoma mansoni	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+	-	Schistosoma mansoni	2-nitro-5-thiobenzoate + NADP+	-	?
GSSG + NADPH + H+	-	Schistosoma mansoni	glutathione + NADP+	-	?

Synonyms

Synonyms	Comment	Organism
SmTGR	-	Schistosoma mansoni
thioredoxin glutathione reductase	-	Schistosoma mansoni

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
0.19	-	GSSG	-	Schistosoma mansoni
1.2	-	5,5'-dithiobis(2-nitrobenzoic acid)	-	Schistosoma mansoni

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Release 2023.1 (January 2023)