Crystallization (Comment) | Organism |
---|---|
crystallization of the enzyme in complex with 1,8-naphthyridine-2 carboxylate and with the 1-(2-hydroxyethyl)piperazine derivatives, sitting drop vapor diffusion method | Schistosoma mansoni |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,8-naphthyridine-2 carboxylate | mixed inhibition. 1,8-Naphthyridine-2 carboxylate prevents Tyr296 from rotating, a process necessary for NADPH binding and enzyme reduction. It inhibits by stabilizing a protein conformation whose affinity for NADPH is greatly reduced | Schistosoma mansoni |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Schistosoma mansoni | Q962Y6 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Schistosoma mansoni |
Synonyms | Comment | Organism |
---|---|---|
TGR | - |
Schistosoma mansoni |
thioredoxin glutathione reductase | - |
Schistosoma mansoni |
General Information | Comment | Organism |
---|---|---|
drug target | promising drug target for the treatment of schistosomiasis | Schistosoma mansoni |