Crystallization (Comment) | Organism |
---|---|
sitting drop method | Schistosoma mansoni |
Protein Variants | Comment | Organism |
---|---|---|
E330A/D334A | mutation of two key residues interacting with the inhibitor 4-aminopiazthiole. Inhibition at 0.5 mM 4-aminopiazthiole is indistinguishable from that of the wild type enzyme | Schistosoma mansoni |
E337A | mutation of E337 an interacting residue of the inhibitor indole-3-carbinol, Inhibition at 0.5 mM indole-3-carbinol is indistinguishable from that of the wild type enzyme | Schistosoma mansoni |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-aminopiazthiole | inhibit the enzyme in a NADPH-dependent manner, and the inhibition appears to be irreversible even upon extensive dilution of the inhibited protein | Schistosoma mansoni | |
indole-3-carbinol | inhibit the enzyme in a NADPH-dependent manner, and the inhibition appears to be irreversible even upon extensive dilution of the inhibited protein | Schistosoma mansoni |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Schistosoma mansoni | A0A3Q0KFL1 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
TGR | - |
Schistosoma mansoni |
thioredoxin glutathione reductase | - |
Schistosoma mansoni |