Literature summary for 1.8.1.B1 extracted from

Salinas, G.; Gao, W.; Wang, Y.; Bonilla, M.; Yu, L.; Novikov, A.; Virginio, V.G.; Ferreira, H.B.; Vieites, M.; Gladyshev, V.N.; Gambino, D.; Dai, S.
The enzymatic and structural basis for inhibition of Echinococcus granulosus thioredoxin glutathione reductase by gold(I) (2017), Antioxid. Redox Signal., 27, 1491-1504 .

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Echinococcus granulosus

Protein Variants

Protein Variants	Comment	Organism
C519S	the selenium content of wild-type enzyme and the C519S mutant enzyme is 17% and 15%, respectively	Echinococcus granulosus
C573S	the selenium content of wild-type enzyme and the C574S mutant enzyme is 17% and 15%, respectively	Echinococcus granulosus

Inhibitors

Inhibitors	Comment	Organism	Structure
AuI-pyridine-2-thiol N-oxide	a potent inhibitor that achieves 75% inhibition at a 1:1 thioredoxin glutathione reductase:Au ratio and efficiently kills Echinococcus granulosus in vitro	Echinococcus granulosus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
selenium	Sec-containing redox center. The selenium content of wild-type enzyme and C519S mutant enzyme and C574S mutant enzyme is 17%, 15%, and 15%	Echinococcus granulosus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
glutathione disulfide + NADPH + H+	Echinococcus granulosus	-	2 glutathione + NADP+	-	?
thioredoxin disulfide + NADPH + H+	Echinococcus granulosus	-	thioredoxin + NADP+	-	?

Organism

Organism	UniProt	Comment	Textmining
Echinococcus granulosus	Q869D7	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Echinococcus granulosus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
glutathione disulfide + NADPH + H+	-	Echinococcus granulosus	2 glutathione + NADP+	-	?
thioredoxin disulfide + NADPH + H+	-	Echinococcus granulosus	thioredoxin + NADP+	-	?

Subunits

Subunits	Comment	Organism
homodimer	-	Echinococcus granulosus

Synonyms

Synonyms	Comment	Organism
TGR	-	Echinococcus granulosus
thioredoxin glutathione reductase	-	Echinococcus granulosus

Cofactor

Cofactor	Comment	Organism	Structure
FAD	-	Echinococcus granulosus

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Release 2023.1 (January 2023)