Literature summary for 1.8.3.1 extracted from

Herken, E.N.; Kocamaz, E.; Erel, O.; Celik, H.; Kucukatay, V.
Effect of sulfite treatment on total antioxidant capacity, total oxidant status, lipid hydroperoxide, and total free sulfydryl groups contents in normal and sulfite oxidase-deficient rat plasma (2008), Cell Biol. Toxicol., 25, 355-362.

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Application

Application	Comment	Organism
additional information	sulfite treatment may cause oxidative stress, and SOX normal animal copes with this stressful condition due to oxidative/antioxidative balance, whereas SOX-deficent rats, which are an exaggerated model for the normal human situation, cannot handle the sulfite-dependent oxidative stress	Rattus norvegicus

Protein Variants

Protein Variants	Comment	Organism
additional information	SOX activity in SOX-deficient animals is significantly reduced by 95-99%. In SOX-deficient rats, sulfite treatment causes a significant increase in the plasma lipid hydroperoxide and total oxidant status levels, while -SH content of rat plasma significantly decreases compared to the control. Significant decrease in plasma total antioxidant capacity level by sulfite treatment	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	maintaining the animal on low-molybdenum, high-tungsten diet, leads to an effective production of SOX deficiency	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood plasma	-	Rattus norvegicus	-
liver	-	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
SOX	-	Rattus norvegicus

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Release 2023.1 (January 2023)