Application | Comment | Organism |
---|---|---|
diagnostics | the expression of QSOX1 in neuroblastoma tumors may influence its clinical course because this protein is involved in processes such as the maturation of the extracellular matrix and the induction of apoptosis in these tumors. The enzyme can be used as a prognostic biomarker to help better discriminate among risk groups | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
extracellular | - |
Homo sapiens | - |
- |
Golgi apparatus | - |
Homo sapiens | 5794 | - |
mitochondrion | - |
Homo sapiens | 5739 | - |
secretory granule | - |
Homo sapiens | 30141 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O00391 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
neuroblastoma cell | immunohistochemical expression of the protein quiescin sulfhydryl oxidase 1 (QSOX1) in samples obtained from untreated neuroblastomas with the patients' clinical and pathological prognostic factors and clinical course. The immunoexpression of QSOX1 correlates with the type of tumor stroma and is higher in Schwannian stroma-rich tumors. Statistically significant correlation between QSOX1 expression and well-differentiated neuroblastomas | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
QSOx1 | - |
Homo sapiens |
quiescin sulfhydryl oxidase 1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the extracellular location of QSOX proteins suggests that they may be involved in the remodelling of the extracellular matrix, particularly because QSOX can catalyse the formation of disulfide bridges, which are needed for the appropriate folding and stability of various matrix proteins. The expression of QSOX1 in neuroblastoma tumors may influence its clinical course because this protein is involved in processes such as the maturation of the extracellular matrix and the induction of apoptosis in these tumors | Homo sapiens |