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Literature summary for 1.8.3.4 extracted from

  • Pol, A.; Renkema, G.H.; Tangerman, A.; Winkel, E.G.; Engelke, U.F.; de Brouwer, A.P.M.; Lloyd, K.C.; Araiza, R.S.; van den Heuvel, L.; Omran, H.; Olbrich, H.; Oude Elberink, M.; Gilissen, C.; Rodenburg, R.J.; Sass, J.O.; Schwab, K.O.; Schaefer, H.; Venselaar, H.; Sequeira, J.S.; Op den Camp, H.J.M.; Wevers, R.A.
    Mutations in SELENBP1, encoding a novel human methanethiol oxidase, cause extraoral halitosis (2018), Nat. Genet., 50, 120-129 .
    View publication on PubMedView publication on EuropePMC
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KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0048
-
 methanethiol pH and temperature not specified in the publication Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
methanethiol + O2 + H2O Homo sapiens
-
 formaldehyde + hydrogen sulfide + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q13228
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
duodenum
-
 Homo sapiens
-
kidney
-
 Homo sapiens
-
liver
-
 Homo sapiens
-
lung
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
methanethiol + O2 + H2O
-
 Homo sapiens formaldehyde + hydrogen sulfide + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
MTO
-
 Homo sapiens
SELENBP1
-
 Homo sapiens
selenium binding protein 1
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction an inborn error of metabolism caused by methanethiol oxidase-deficiency leads to a malodor syndrome Homo sapiens