Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.8.3.4 extracted from

  • Philipp, T.M.; Will, A.; Richter, H.; Winterhalter, P.R.; Pohnert, G.; Steinbrenner, H.; Klotz, L.O.
    A coupled enzyme assay for detection of selenium-binding protein 1 (SELENBP1) methanethiol oxidase (MTO) activity in mature enterocytes (2021), Redox Biol., 43, 101972 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.8.3.4

Protein Variants

Protein Variants Comment Organism
G225W the mutant is identified in individuals with extraoral halitosis. Inactive mutant enzyme Homo sapiens
H329Y the mutant is identified in individuals with extraoral halitosis. Inactive mutant enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
methanethiol + O2 + H2O Homo sapiens
-
 formaldehyde + hydrogen sulfide + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q13228
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Caco-2 cell methanethiol oxidase activity is strongly enhanced in Caco-2 cells upon enterocyte differentiation, in parallel with increased SELENBP1 levels Homo sapiens
-
enterocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
methanethiol + O2 + H2O
-
 Homo sapiens formaldehyde + hydrogen sulfide + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
methanethiol oxidase
-
 Homo sapiens
MTO
-
 Homo sapiens
SELENBP1
-
 Homo sapiens
selenium-binding protein 1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens methanethiol oxidase activity is strongly enhanced in Caco-2 cells upon enterocyte differentiation, in parallel with increased SELENBP1 levels up

General Information

General Information Comment Organism
physiological function mature enterocytes located at the tip of colonic crypts are capable of eliminating microbiome-derived methanethiol Homo sapiens