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Literature summary for 1.8.3.7 extracted from
- Two-fold bioorthogonal derivatization by different formylglycine-generating enzymes (2018), Angew. Chem. Int. Ed. Engl., 57, 7245-7249 .
Application
| Application | Comment | Organism |
|---|---|---|
| biotechnology | bioconjugation chemistry, formylglycine-generating enzymes catalyze the site-specific oxidation of a cysteine residue to the aldehyde-containing amino acid Ca-formylglycine (FGly). This noncanonical residue can be generated within any desired target protein and can subsequently be used for bioorthogonal conjugation reactions | Mycobacterium tuberculosis |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycobacterium tuberculosis | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| a [sulfatase]-L-cysteine + O2 + 2 a thiol | almost exclusively converts the cysteine within the CTPSR motif | Mycobacterium tuberculosis | a [sulfatase]-3-oxo-L-alanine + hydrogen sulfide + a disulfide + H2O | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| FGE | - |
Mycobacterium tuberculosis |
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Release 2023.1 (January 2023)
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