Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of MsrA-deficient mutant mice, the mutant mice show tip-toe-walking, reduced lifespan under hyperoxic conditions and increased sensitivity to oxidative stress compared to wild-type mice, phenotype overview | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-methionine-(S)-S-oxide + thioredoxin | Mus musculus | stereospecific reduction | L-methionine + thioredoxin disulfide + H2O | - |
? | |
additional information | Mus musculus | MsrA is a regulator of antioxidant defense and lifespan in mammals | ? | - |
? | |
peptide-L-methionine-(S)-S-oxide + thioredoxin | Mus musculus | stereospecific reduction | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
C57BL76J mice, gene msrA | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
kidney | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
lung | - |
Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
activities in wild-type and mutant mice in different organs during 2 days, overview | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dabsyl-L-methionine-(S)-S-oxide + thioredoxin | stereospecific reduction | Mus musculus | dabsyl-L-methionine + thioredoxin disulfide + H2O | - |
? | |
L-methionine-(S)-S-oxide + thioredoxin | stereospecific reduction | Mus musculus | L-methionine + thioredoxin disulfide + H2O | - |
? | |
L-methionine-(S)-S-oxide + thioredoxin | stereospecific reduction, free methionine-(S)-S-oxide | Mus musculus | L-methionine + thioredoxin disulfide + H2O | - |
? | |
additional information | MsrA is a regulator of antioxidant defense and lifespan in mammals | Mus musculus | ? | - |
? | |
peptide-L-methionine-(S)-S-oxide + thioredoxin | stereospecific reduction | Mus musculus | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
methionine sulfoxide reductase | - |
Mus musculus |
MsrA | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
thioredoxin | - |
Mus musculus |