Cloned (Comment) | Organism |
---|---|
mitochondrial and cytosolic isozymes are encoded by a single gene | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | cytosolic isozyme of MsrA | Rattus norvegicus | 5829 | - |
mitochondrion | matrix, mitochondrial isozyme of MsrA | Rattus norvegicus | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
protein-L-methionine (S)-sulfoxide + thioredoxin | Rattus norvegicus | MsrA is specific for the S-form, enzyme provides protection against oxidative damage by reactive oxygen species and has a repair function for oxidized protein methionine residues | protein-L-methionine + thioredoxin disulfide + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
2 isozymes of MsrA | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | enzyme precursor contains a cleavable N-terminal signal sequence for targeting to the mitochondria | Rattus norvegicus |
Purification (Comment) | Organism |
---|---|
MsrA from cytosolic and mitochondrial fractions | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.0002 | - |
cytosol, overall Msr activity, substrate is a mixture of S- and R-form of dabsyl L-methionine sulfoxide | Rattus norvegicus |
0.00021 | - |
mitochondria, overall Msr activity, substrate is a mixture of S- and R-form of dabsyl L-methionine sulfoxide | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dabsyl-L-methionine (S)-sulfoxide + thioredoxin | synthetic substrate | Rattus norvegicus | dabsyl-L-methionine + thioredoxin disulfide + H2O | - |
? | |
protein-L-methionine (S)-sulfoxide + thioredoxin | MsrA is specific for the S-form | Rattus norvegicus | protein-L-methionine + thioredoxin disulfide + H2O | - |
? | |
protein-L-methionine (S)-sulfoxide + thioredoxin | MsrA is specific for the S-form, enzyme provides protection against oxidative damage by reactive oxygen species and has a repair function for oxidized protein methionine residues | Rattus norvegicus | protein-L-methionine + thioredoxin disulfide + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
methionine sulphoxide reductase A | - |
Rattus norvegicus |
MsrA | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
thioredoxin | - |
Rattus norvegicus |