Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Mus musculus | 5829 | - |
cytosol | - |
Rattus norvegicus | 5829 | - |
cytosol | - |
Homo sapiens | 5829 | - |
mitochondrion | - |
Mus musculus | 5739 | - |
mitochondrion | - |
Rattus norvegicus | 5739 | - |
mitochondrion | - |
Homo sapiens | 5739 | - |
nucleus | - |
Mus musculus | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | MsrA null mutant mice exhibit a shortened lifespan and present higher levels of protein carbonyls when exposed to hyperoxia, which indicates an increased sensitivity towards oxidative stress | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9UJ68 | - |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
alveolar macrophage | - |
Rattus norvegicus | - |
blood | - |
Rattus norvegicus | - |
cerebellum | - |
Homo sapiens | - |
epidermis | chronic sun exposure of human epidermis and high dose UVA irradiation of cultured human keratinocytes results in a decline of MsrA expression and/or Msr activity | Homo sapiens | - |
fibroblast | overexpression of MsrA protects immortalized WI-38 SV40 human fibroblasts against H2O2mediated oxidative stress by reducing the amount of intracellular reactive oxygen species and the extent of irreversible protein oxidative damage | Homo sapiens | - |
keratinocyte | chronic sun exposure of human epidermis and high dose UVA irradiation of cultured human keratinocytes results in a decline of MsrA expression and/or Msr activity | Homo sapiens | - |
kidney | - |
Rattus norvegicus | - |
kidney | MsrA mRNA is highly expressed | Homo sapiens | - |
lens | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
melanocyte | - |
Homo sapiens | - |
nervous system | - |
Rattus norvegicus | - |
neuron | - |
Rattus norvegicus | - |
renal medulla | - |
Rattus norvegicus | - |
retinal pigment epithelium | - |
Rattus norvegicus | - |
skin | MsrA exhibits a strong expression in keratinocytes and melanocytes and a lower expression in dermal fibroblasts. Repetitive exposure of human skin to solar-stimulated light results in an enhanced expression of MsrA in the epidermis. Exposure to relatively high doses of UVA results in a downregulation of MsrA. Chronic sun-exposure, would result in a decreased expression of two main components of the methionine sulfoxide reductase system, MsrA and MsrB2 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | MsrA null mutant mice exhibit a shortened lifespan and present higher levels of protein carbonyls when exposed to hyperoxia, which indicates an increased sensitivity towards oxidative stress | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MsrA | - |
Mus musculus |
MsrA | - |
Rattus norvegicus |
MsrA | - |
Homo sapiens |