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Literature summary for 1.8.4.11 extracted from

  • Liu, F.; Hindupur, J.; Nguyen, J.L.; Ruf, K.J.; Zhu, J.; Schieler, J.L.; Bonham, C.C.; Wood, K.V.; Davisson, V.J.; Rochet, J.C.
    Methionine sulfoxide reductase A protects dopaminergic cells from Parkinsons disease-related insults (2008), Free Radic. Biol. Med., 45, 242-255.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine MsrA efficiently reduces oxidized methionine residues in recombinant alpha-synuclein. Enhancing MsrA function may be a reasonable therapeutic strategy in Parkinson's disease Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
peptide-L-methionine (S)-S-oxide + thioredoxin Bos taurus MsrA suppresses dopaminergic cell death and protein aggregation induced by the complex I inhibitor rotenone or mutant alpha-synuclein, but not by the proteasome inhibitor MG132. MsrA protects against Parkinson's disease-related stresses primarily via methionine sulfoxide repair rather than by scavenging reactive oxygen species peptide-L-methionine + thioredoxin disulfide + H2O
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Organism

Organism UniProt Comment Textmining
Bos taurus P54149 recombinant
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Purification (Commentary)

Purification (Comment) Organism
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Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-synuclein-L-methionine (S)-S-oxide + thioredoxin
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Bos taurus alpha-synuclein-L-methionine + thioredoxin disulfide + H2O
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peptide-L-methionine (S)-S-oxide + thioredoxin MsrA suppresses dopaminergic cell death and protein aggregation induced by the complex I inhibitor rotenone or mutant alpha-synuclein, but not by the proteasome inhibitor MG132. MsrA protects against Parkinson's disease-related stresses primarily via methionine sulfoxide repair rather than by scavenging reactive oxygen species Bos taurus peptide-L-methionine + thioredoxin disulfide + H2O
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?

Synonyms

Synonyms Comment Organism
methionine sulfoxide reductase A
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Bos taurus
MsrA
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Bos taurus