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Literature summary for 1.8.4.11 extracted from
- Methionine sulfoxide reductase A deficiency exacerbates acute liver injury induced by acetaminophen (2017), Biochem. Biophys. Res. Commun., 484, 189-194 .
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Mus musculus | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q9D6Y7 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| hepatocyte | primary hepatocyte | Mus musculus | - |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | MsrA gene-deleted (MsrA-/-) hepatocytes show higher susceptibility to acetaminophen-induced cytotoxicity than wild-type cells. MsrA deficiency increases acetaminophen-induced glutathione depletion and reactive oxygen species production. Acetaminophen-treatment increases Nrf2 activation more profoundly in MsrA-/- than in wild-type hepatocytes, and basal thioredoxin reductase 1 levels are significantly higher in MsrA-/- than in wild-type hepatocytes | Mus musculus |
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Release 2023.1 (January 2023)
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