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Literature summary for 1.8.4.11 extracted from
- Leishmania major methionine sulfoxide reductase A is required for resistance to oxidative stress and efficient replication in macrophages (2013), PLoS ONE, 8, e56064 .
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Leishmania major | 5737 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Leishmania major | Q4QIH2 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| LMJF_07_1140 | - |
Leishmania major |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | a MsrA null mutant is viable in rich medium but is unable to reduce exogenous methionine sulfoxide when cultivated in the presence of this amino acid. The mutant exhibits increased sensitivity to H2O2 compared to wild type parasites and is unable to proliferate normally in macrophages. The mutant is able to induce normal lesions in susceptible BALB/c mice | Leishmania major |
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Release 2023.1 (January 2023)
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