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Literature summary for 1.8.4.12 extracted from

  • Sagher, D.; Brunell, D.; Hejtmancik, J.F.; Kantorow, M.; Brot, N.; Weissbach, H.
    Thionein can serve as a reducing agent for the methionine sulfoxide reductases (2006), Proc. Natl. Acad. Sci. USA, 103, 8656-8661.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-methionine-(R)-S-oxide + thioredoxin Escherichia coli the cofactor thioredoxin can be recycled in vivo by thionein due to its high content of cysteines, overview L-methionine + thioredoxin disulfide + H2O
-
 ?
L-methionine-(R)-S-oxide + thioredoxin Homo sapiens the cofactor thioredoxin can be recycled in vivo by thionein due to its high content of cysteines, overview L-methionine + thioredoxin disulfide + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Homo sapiens
-
 isozyme MsrB2
-

Reaction

Reaction Comment Organism Reaction ID
peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin catalytic mechanism and the role of cofactor recycling in vivo Escherichia coli
a
peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin catalytic mechanism and the role of cofactor recycling in vivo Homo sapiens
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-methionine-(R)-S-oxide + DTT
-
 Escherichia coli L-methionine + DTT disulfide + H2O
-
 ?
L-methionine-(R)-S-oxide + DTT
-
 Homo sapiens L-methionine + DTT disulfide + H2O
-
 ?
L-methionine-(R)-S-oxide + thioredoxin
-
 Escherichia coli L-methionine + thioredoxin disulfide + H2O
-
 ?
L-methionine-(R)-S-oxide + thioredoxin
-
 Homo sapiens L-methionine + thioredoxin disulfide + H2O
-
 ?
L-methionine-(R)-S-oxide + thioredoxin the cofactor thioredoxin can be recycled in vivo by thionein due to its high content of cysteines, overview Escherichia coli L-methionine + thioredoxin disulfide + H2O
-
 ?
L-methionine-(R)-S-oxide + thioredoxin the cofactor thioredoxin can be recycled in vivo by thionein due to its high content of cysteines, overview Homo sapiens L-methionine + thioredoxin disulfide + H2O
-
 ?

Synonyms

Synonyms Comment Organism
MsrB
-
 Escherichia coli
MsrB
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
dithiothreitol can act as cofactor only in vitro showing a much higher activity than thioredoxin Homo sapiens
dithiothreitol can substitute for thioredoxin in vitro Escherichia coli
thioredoxin natural cofactor, the cofactor can be recycled in vivo by reduction via zinc-containing metallothionein, Zn-MT, after removal of the zinc ion due to its high content of cysteines, mechanism, overview Homo sapiens
thioredoxin preferred and natural cofactor, the cofactor can be recycled in vivo by reduction via zinc-containing metallothionein, Zn-MT, after removal of the zinc ion due to its high content of cysteines, mechanism, overview Escherichia coli