Application | Comment | Organism |
---|---|---|
synthesis | application of methionine sulfoxide reductase B for preparation of (S)-sulfoxides through kinetic resolution of racemic sulfoxides. The kinetic resolution of rac-sulfoxides is successfully accomplished at substrate concentrations up to 50 mM (7.8 g/l) when catalyzed by akMsrB whole-cell catalyst. The study supports that asymmetric reductive resolution of rac-sulfoxides catalysed by MsrB can become an effective strategy for green synthesis of optically pure sulfoxides | Acidovorax sp. KKS102 |
Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Acidovorax sp. KKS102 |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Acidovorax sp. KKS102 | K0HZZ3 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
racemic (ethanesulfinyl)benzene + dithiothreitol | specifically reduces the (R)-enantiomer of methionine sulfoxide to methionine, 93.1% ee | Acidovorax sp. KKS102 | (ethylsulfanyl)benzene + [(S)-ethanesulfinyl]benzene + dithiothreitol disulfide + H2O | - |
? | |
racemic (methanesulfinyl)benzene + dithiothreitol | specifically reduces the (R)-enantiomer of methionine sulfoxide to methionine, 96% ee | Acidovorax sp. KKS102 | (methylsulfanyl)benzene + [(S)-methanesulfinyl]benzene + dithiothreitol disulfide + H2O | - |
? | |
racemic 1-(methanesulfinyl)-4-methylbenzene + dithiothreitol | specifically reduces the (R)-enantiomer of methionine sulfoxide to methionine, 96.4% ee | Acidovorax sp. KKS102 | 1-methyl-4-(methylsulfanyl)benzene + 1-[(S)-methanesulfinyl]-4-methylbenzene + dithiothreitol disulfide + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
methionine sulfoxide reductase B | - |
Acidovorax sp. KKS102 |
MsrB | - |
Acidovorax sp. KKS102 |