Literature summary for 1.8.4.12 extracted from

He, Q.; Li, H.; Meng, F.; Sun, X.; Feng, X.; Chen, J.; Li, L.; Liu, J.
Methionine sulfoxide reductase B1 regulates hepatocellular carcinoma cell proliferation and invasion via the mitogen-activated protein kinase pathway and epithelial-mesenchymal transition (2018), Oxid. Med. Cell. Longev., 2018, 5287971 .

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Metals/Ions

Metals/Ions	Comment	Organism	Structure
selenium	selenoprotein	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9NZV6	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hepatoma cell	MsrB1 is highly expressed in HCC tissues and its expression correlates with the prognoses of patients with HCC after hepatectomy	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
methionine sulfoxide reductase B1	-	Homo sapiens
MSRB1	-	Homo sapiens

General Information

General Information	Comment	Organism
drug target	the enzyme (MsrB1) may be a therapeutic target with respect to the treatment of hepatocellular carcinoma	Homo sapiens
malfunction	MsrB1 knockdown effectively inhibits tumor growth. MsrB1 knockdown reduces hepatocellular carcinoma cell migration and invasion in a transwell assay through inhibition of cytoskeletal rearrangement and spread	Homo sapiens
physiological function	methionine sulfoxide reductase B1 regulates hepatocellular carcinoma cell proliferation and invasion via the mitogen-activated protein kinase pathway and epithelial-mesenchymal transition	Homo sapiens

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Release 2023.1 (January 2023)