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Literature summary for 1.8.4.13 extracted from

  • Weissbach, H.; Resnick, L.; Brot, N.
    Methionine sulfoxide reductases: history and cellular role in protecting against oxidative damage (2005), Biochim. Biophys. Acta, 1703, 203-212.
    View publication on PubMed

Application

Application Comment Organism
synthesis enzyme can be useful in the development and action of anti-cancer and anti-inflammation drugs Escherichia coli

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane enzyme form Mem-R,S-Msr Escherichia coli 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-methionine (S)-sulfoxide + NADPH + H+ Escherichia coli membrane-bound enzyme form Mem-R,S-Msr L-methionine + NADP+ + H2O
-
?
additional information Escherichia coli the enzyme protects cells against oxidative damage and plays a role in age-related misfunctions ?
-
?
sulindac + NADPH Escherichia coli activation of a methionine sulfoxide-containing prodrug, activity with membrane-bound enzyme form Mem-R,S-Msr sulindac sulfide + NADP+ + H2O activated drug which inhibits cyclooxygenase 1 and 2 and exhibits anti-inflammatory activity ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
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-
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Escherichia coli
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isozyme Mem-R,S-Msr, bifunctional enzyme
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [Āµmol/min/mg] Specific Activity Maximum [Āµmol/min/mg] Comment Organism
0.00009
-
enzyme form Mem-R,S-Msr, substrate sulindac Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-methionine (S)-sulfoxide + NADPH + H+ membrane-bound enzyme form Mem-R,S-Msr Escherichia coli L-methionine + NADP+ + H2O
-
?
L-methionine sulfoxide enkephalin + NADPH membrane-bound enzyme form Mem-R,S-Msr Escherichia coli L-methionine enkephalin + NADP+ + H2O
-
?
L-methionine-(S)-S-oxide + thioredoxin
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Escherichia coli L-methionine + thioredoxin disulfide + H2O
-
?
additional information the enzyme protects cells against oxidative damage and plays a role in age-related misfunctions Escherichia coli ?
-
?
additional information substrate specificity, overview, Mem-R,S-Msr can also catalyze the reduction of L-methionine (R)-sulfoxide, EC 1.8.4.14, enzyme reduces oxidized methionine residues of the ribosomal protein L12, which becomes reversibly inactivated and forms monomers instead of dimers upon oxidation Escherichia coli ?
-
?
additional information no activity with peptide-L-methionine-(S)-S-oxide Escherichia coli ?
-
?
N-acetyl-L-methionine (S)-sulfoxide + thioredoxin membrane-bound enzyme form Mem-R,S-Msr Escherichia coli N-acetyl-L-methionine + thioredoxin disulfide + H2O
-
?
sulindac + NADPH activation of a methionine sulfoxide-containing prodrug, activity with membrane-bound enzyme form Mem-R,S-Msr Escherichia coli sulindac sulfide + NADP+ + H2O activated drug which inhibits cyclooxygenase 1 and 2 and exhibits anti-inflammatory activity ?
sulindac + NADPH activity with membrane-bound enzyme form Mem-R,S-Msr Escherichia coli sulindac sulfide + NADP+ + H2O
-
?

Synonyms

Synonyms Comment Organism
fSMsr
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Escherichia coli

Cofactor

Cofactor Comment Organism Structure
additional information no activity with DTT as cofactor by membrane-bound enzyme form Mem-R,S-Msr Escherichia coli
NADPH membrane-bound enzyme form Mem-R,S-Msr Escherichia coli