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Literature summary for 1.8.4.2 extracted from

  • Varandani, P.T.; Plumley, H.
    Mechanism of action of glutathione-insulin transhydrogenase. Presence of a functional sulfhydryl group for activity (1968), Biochim. Biophys. Acta, 151, 273-275.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
iodoacetamide treatment with thiol prior to incubation with GSH and substrate: no inhibition, preincubation with GSH and thiol reagent: inhibition Bos taurus
iodoacetate treatment with thiol prior to incubation with GSH and substrate: no inhibition, preincubation with GSH and thiol reagent: inhibition Bos taurus
N-ethylmaleimide treatment with thiol prior to incubation with GSH and substrate: no inhibition, preincubation with GSH and thiol reagent: inhibition Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
58000
-
gel filtration Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
pancreas
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GSH + insulin
-
Bos taurus GSSG + reduced insulin chain A and B
-
?
GSH + protein disulfide
-
Bos taurus GSSG + protein-dithiol
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Bos taurus