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Literature summary for 1.8.4.2 extracted from
- Role of disulfide interchange enzyme in immunoglobulin synthesis (1981), Biochemistry, 20, 6594-6599.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| EDTA | activates | Mus musculus |  |
General Stability
| General Stability | Organism |
|---|---|
| highly susceptible to proteolytic attack | Mus musculus |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 60000 | - |
SDS-PAGE | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GSH + protein disulfide | Mus musculus | synthesis of protein disulfide bond | GSSG + protein-dithiol | - |
? | |
| GSH + protein disulfide | Mus musculus | enzyme plays a role in formation of intramonomer bonds common to all immunoglobulin molecules | GSSG + protein-dithiol | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| lymphoid tissue | - |
Mus musculus | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 4°C, 90% of the enzyme is converted from its native form with MW 60000 to a fragment of MW 40000-45000 | Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GSH + protein disulfide | - |
Mus musculus | GSSG + protein-dithiol | - |
? | |
| GSH + protein disulfide | synthesis of protein disulfide bond | Mus musculus | GSSG + protein-dithiol | - |
? | |
| GSH + protein disulfide | enzyme plays a role in formation of intramonomer bonds common to all immunoglobulin molecules | Mus musculus | GSSG + protein-dithiol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| disulphide interchange enzyme | - |
Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
- |
Mus musculus |
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