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Literature summary for 1.8.4.2 extracted from
- Protein disulfide oxidoreductases in bacteria (1994), Trends Biochem. Sci., 19, 169-171.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| periplasm | - |
Escherichia coli | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 21100 | - |
DsbA gene product | Escherichia coli |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GSH + protein disulfide | Escherichia coli | disulfide bonding step in folding pathway of many periplasmic and outer membrane proteins with structural disulfide bonds | GSSG + protein-dithiol | - |
r |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
| Haemophilus influenzae | - |
DsbA homologous | - |
| Haemophilus influenzae | - |
Por gene | - |
| Haemophilus influenzae DsbA homologous | - |
DsbA homologous | - |
| Vibrio cholerae serotype O1 | - |
tcpG gene | - |
| Vibrio cholerae serotype O1 | - |
DsbA homologous | - |
| Vibrio cholerae serotype O1 DsbA homologous | - |
DsbA homologous | - |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| 2 glutathione + protein-disulfide = glutathione-disulfide + protein-dithiol | C-X-X-C motif in active site for disulfide bonding, either oxidizing, reducing and isomerising activity | Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GSH + protein disulfide | disulfide bonding step in folding pathway of many periplasmic and outer membrane proteins with structural disulfide bonds | Escherichia coli | GSSG + protein-dithiol | - |
r | |
| additional information | DsbB protein re-oxidizes the reduced DsbA protein | Escherichia coli | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| More | DsbA protein family including periplasmic protein disulfide: thiol oxidoreductases with high homology in amino acid sequences | Escherichia coli |
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Release 2023.1 (January 2023)
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