BRENDA - Enzyme Database
show all sequences of 1.8.4.4

Thiol-disulfide transhydrogenase from baker's yeast and a new method for the direct assay of an enzyme-catalyzed thiol-disulfide interchange activity

Minoda, Y.; Kurane, R.; Yamada, K.; Agric. Biol. Chem. 37, 2511-2516 (1973)
No PubMed abstract available

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
EDTA
-
Saccharomyces cerevisiae
Inhibitors
Inhibitors
Commentary
Organism
Structure
Cd2+
-
Saccharomyces cerevisiae
Co2+
-
Saccharomyces cerevisiae
Cu2+
-
Saccharomyces cerevisiae
Hg2+
-
Saccharomyces cerevisiae
iodoacetate
-
Saccharomyces cerevisiae
Mn2+
-
Saccharomyces cerevisiae
MoO3
-
Saccharomyces cerevisiae
Na2HAsO4
-
Saccharomyces cerevisiae
Zn2+
-
Saccharomyces cerevisiae
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
cystine + GSH
Saccharomyces cerevisiae
-
cysteine + GSSG
-
-
?
Organism
Organism
UniProt
Commentary
Textmining
Saccharomyces cerevisiae
-
-
-
Purification (Commentary)
Purification (Commentary)
Organism
-
Saccharomyces cerevisiae
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
cystine + GSH
-
395016
Saccharomyces cerevisiae
cysteine + GSSG
-
-
-
?
dimethyl disulfide + GSH
-
395016
Saccharomyces cerevisiae
?
-
-
-
?
dithiodiglycolic acid + GSH
-
395016
Saccharomyces cerevisiae
?
-
-
-
?
GSSG + GSH
-
395016
Saccharomyces cerevisiae
GSSG + GSH
-
-
-
?
homocystine + GSH
-
395016
Saccharomyces cerevisiae
?
-
-
-
?
lipoic acid oxidized + GSH
-
395016
Saccharomyces cerevisiae
?
-
-
-
?
additional information
inactive with albumin and kreatin
395016
Saccharomyces cerevisiae
?
-
-
-
?
additional information
at low substrate concentration the reaction rate is greater with L-cystine than with any of the other substances
395016
Saccharomyces cerevisiae
?
-
-
-
?
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
EDTA
-
Saccharomyces cerevisiae
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
Cd2+
-
Saccharomyces cerevisiae
Co2+
-
Saccharomyces cerevisiae
Cu2+
-
Saccharomyces cerevisiae
Hg2+
-
Saccharomyces cerevisiae
iodoacetate
-
Saccharomyces cerevisiae
Mn2+
-
Saccharomyces cerevisiae
MoO3
-
Saccharomyces cerevisiae
Na2HAsO4
-
Saccharomyces cerevisiae
Zn2+
-
Saccharomyces cerevisiae
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
cystine + GSH
Saccharomyces cerevisiae
-
cysteine + GSSG
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
-
Saccharomyces cerevisiae
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
cystine + GSH
-
395016
Saccharomyces cerevisiae
cysteine + GSSG
-
-
-
?
dimethyl disulfide + GSH
-
395016
Saccharomyces cerevisiae
?
-
-
-
?
dithiodiglycolic acid + GSH
-
395016
Saccharomyces cerevisiae
?
-
-
-
?
GSSG + GSH
-
395016
Saccharomyces cerevisiae
GSSG + GSH
-
-
-
?
homocystine + GSH
-
395016
Saccharomyces cerevisiae
?
-
-
-
?
lipoic acid oxidized + GSH
-
395016
Saccharomyces cerevisiae
?
-
-
-
?
additional information
inactive with albumin and kreatin
395016
Saccharomyces cerevisiae
?
-
-
-
?
additional information
at low substrate concentration the reaction rate is greater with L-cystine than with any of the other substances
395016
Saccharomyces cerevisiae
?
-
-
-
?
Other publictions for EC 1.8.4.4
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
395016
Minoda
-
Thiol-disulfide transhydrogena ...
Saccharomyces cerevisiae
Agric. Biol. Chem.
37
2511-2516
1973
1
-
-
-
-
-
9
-
-
-
-
1
-
1
-
-
1
-
-
-
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
9
-
-
-
-
-
1
-
-
-
1
-
-
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
395019
States
Interrelationship of glutathio ...
Rattus norvegicus
Biochem. J.
132
623-631
1973
-
-
-
-
-
-
-
2
1
-
-
1
-
3
-
-
-
-
-
2
-
1
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
1
-
-
1
-
-
-
-
-
2
-
1
1
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
395015
Nagai
-
Thiol-disulfide transhydrogena ...
Saccharomyces cerevisiae
Methods Enzymol.
17B
510-515
1971
-
-
-
-
-
2
-
-
1
-
-
1
-
1
-
-
1
-
-
-
1
1
3
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
-
1
-
-
-
1
-
-
1
1
3
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
395018
States
Distribution of glutathione-cy ...
Rattus norvegicus
Biochem. J.
113
443-444
1969
-
-
-
-
-
-
-
-
1
-
-
1
-
3
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
395014
Nagai
A thiol-disulfide transhydroge ...
Saccharomyces cerevisiae
J. Biol. Chem.
243
1942-1947
1968
-
-
-
-
-
6
-
-
1
-
1
1
-
1
-
-
1
-
-
-
1
1
9
-
-
1
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
1
-
1
1
-
-
-
1
-
-
1
1
9
-
1
-
-
-
1
1
-
-
-
-
-
-
-
-
395017
Wendell
Distribution of glutathione re ...
Rattus norvegicus
Biochim. Biophys. Acta
159
179-181
1968
-
-
-
-
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-