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Literature summary for 1.8.5.4 extracted from

  • Liu, D.; Zhang, J.; Lue, C.; Xia, Y.; Liu, H.; Jiao, N.; Xun, L.; Liu, J.
    Synechococcus sp. strain PCC 7002 uses sulfide quinone oxidoreductase to detoxify exogenous sulfide and to convert endogenous sulfide to cellular sulfane sulfur (2020), mBio, 11, e03420-19 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.8.5.4

Protein Variants

Protein Variants Comment Organism
additional information recombinant Escherichia coli expressing SQR and PDO from strain PCC7002 oxidizes sulfide to sulfite and thiosulfate Synechococcus sp. PCC 7002

Inhibitors

Inhibitors Comment Organism Structure
NaHS the growth of the DELTAsqr mutant is fully inhibited while the wild-type and the complementation strain are partly inhibited after treatment with 4-5 mM NaHS Synechococcus sp. PCC 7002

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Synechococcus sp. PCC 7002 SQR oxidizes sulfide to polysulfide, which spontaneously reacts with glutathione (GSH) to produce glutathione persulfide (GSSH), PDO oxidizes GSSH to sulfite, which spontaneously reacts with polysulfide to produce thiosulfate ?
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n H2S + n quinone Synechococcus sp. PCC 7002
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 polysulfide + n quinol
-
 ?

Organism

Organism UniProt Comment Textmining
Synechococcus sp. PCC 7002 B1XRD0
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information SQR oxidizes sulfide to polysulfide, which spontaneously reacts with glutathione (GSH) to produce glutathione persulfide (GSSH), PDO oxidizes GSSH to sulfite, which spontaneously reacts with polysulfide to produce thiosulfate Synechococcus sp. PCC 7002 ?
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-
n H2S + n quinone
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 Synechococcus sp. PCC 7002 polysulfide + n quinol
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 ?

Synonyms

Synonyms Comment Organism
SQR
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 Synechococcus sp. PCC 7002
sulfide:quinone oxidoreductase
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 Synechococcus sp. PCC 7002
type I SQR
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 Synechococcus sp. PCC 7002

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Synechococcus sp. PCC 7002

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Synechococcus sp. PCC 7002

General Information

General Information Comment Organism
malfunction a DELTAsqr mutant contains less cellular sulfur (S0) and has increased expression of key genes involved in photosynthesis, but it is less competitive than the wild-type in cocultures. Strain PCC7002 uses SQR to detoxify exogenous sulfide, enabling it to survive better than its DELTAsqr mutant in sulfide-rich environments. The wild-type strain PCC7002 and the complementation strain PCC7002DELTAsqr::sqr do not accumulate sulfide, but the mutant DELTAsqr does. The DELTAsqr mutant has a higher oxygen evolution rate than the wild-type. The increased oxygen evolution rate upon the DELTAsqr mutant is consistent with an acceleration of H2O oxidation to make up for the loss of H2S oxidation, phenotype, overview Synechococcus sp. PCC 7002
metabolism mammalian mitochondria and heterotrophic bacteria oxidize sulfide via a pathway involving two key enzymes, sulfide:quinone oxidoreductase (SQR) and persulfide dioxygenase (PDO, EC 1.13.11.18). SQR oxidizes sulfide to polysulfide, which spontaneously reacts with glutathione (GSH) to produce glutathione persulfide (GSSH), PDO oxidizes GSSH to sulfite, which spontaneously reacts with polysulfide to produce thiosulfate. This pathway is common in heterotrophic bacteria. The relative electron transport rate (rETR) increases in the mutant Synechococcus sp. PCC 7002
additional information sulfane sulfur is zero valence sulfur in various forms, such as persulfide (RSSH), polysulfide (RSSnH and RSSnR, nx022), and elemental sulfur. Sulfane sulfur can act as either an electrophile or a nucleophile. The nucleophilic property allows cells to resist reactive oxygenspecies, and the electrophilic property causes protein persulfidation, affecting enzyme activities or signaling Synechococcus sp. PCC 7002
physiological function the toxic effect of sulfide is well known, inhibiting respiration by acting on cytochrome c oxidase in heterotrophic bacteria and photosynthesis by binding to metalloproteins of photosynthesis system II (PSII). Sulfide can reach high concentrations in specific habitats, such as hydrothermal vents and seeps and coastal mudflats. Synechococcus sp. strain PCC 7002 uses sulfide:quinone oxidoreductase to detoxify exogenous sulfide and to convert endogenous sulfide to cellular sulfane sulfur. SQR plays a detoxification role. Strain PCC7002 with SQR and persulfide dioxygenase (PDO, EC 1.13.11.18) oxidizes exogenous sulfide to tolerate high sulfide levels. Common presence of SQR in cyanobacteria. SQRs are widely distributed in microorganisms as well as in animal mitochondria. SQR oxidizes sulfide to polysulfide and transfers electrons into the electron transport chain in mitochondria, heterotrophic bacteria, chemolithotrophic bacteria, and photolithotrophic bacteria Synechococcus sp. PCC 7002