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Literature summary for 1.8.5.9 extracted from

  • Halili, M.; Bachu, P.; Lindahl, F.; Bechara, C.; Mohanty, B.; Reid, R.; Scanlon, M.; Robinson, C.; Fairlie, D.; Martin, J.
    Small molecule inhibitors of disulfide bond formation by the bacterial DsbA-DsbB dual enzyme system (2015), ACS Chem. Biol., 10, 957-964 .
    View publication on PubMed
Search for more literature for 1.8.5.9

Inhibitors

Inhibitors Comment Organism Structure
3'-bromo-1-methyl-5-oxo[1,2,5,6-tetrahydro[1,1'-biphenyl]]-3-yl propanoate
-
 Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a [DsbA protein] with reduced L-cysteine residues + a quinone Escherichia coli overall reaction a [DsbA protein] carrying a disulfide bond + a quinol
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a [DsbA protein] with reduced L-cysteine residues + a quinone overall reaction Escherichia coli a [DsbA protein] carrying a disulfide bond + a quinol
-
 ?

Synonyms

Synonyms Comment Organism
DsbB
-
 Escherichia coli

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0011
-
 pH and temperature not specified in the publication Escherichia coli 3'-bromo-1-methyl-5-oxo[1,2,5,6-tetrahydro[1,1'-biphenyl]]-3-yl propanoate