Application | Comment | Organism |
---|---|---|
medicine | increased sulfiredoxin has been linked with oncogenic transformation, data support a role for Srx in controlling the phosphorylation status of key regulatory kinases | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
into the vector pcDNA3 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + R-SH | Homo sapiens | - |
peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
HEK-293 cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | promotes the reversal of cysteine modified PTP1B to its reduced and enzymatically active form | Homo sapiens | ? | - |
? | |
additional information | reduction of cysteine sulfinic acid to sulfenic acid in proteins subject to oxidative stress | Homo sapiens | ? | - |
? | |
peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + R-SH | - |
Homo sapiens | peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R | - |
? |
Synonyms | Comment | Organism |
---|---|---|
protein cysteine sulfinic acid reductase | - |
Homo sapiens |
Srx | - |
Homo sapiens |
sulfiredoxin | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | oxidative stress and growth factors can markedly upregulate Srx transcript and protein levels | up |