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Literature summary for 1.8.98.2 extracted from

  • Lei, K.; Townsend, D.M.; Tew, K.D.
    Protein cysteine sulfinic acid reductase (sulfiredoxin) as a regulator of cell proliferation and drug response (2008), Oncogene, 27, 4877-4887.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine increased sulfiredoxin has been linked with oncogenic transformation, data support a role for Srx in controlling the phosphorylation status of key regulatory kinases Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
into the vector pcDNA3 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + R-SH Homo sapiens
-
peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
Homo sapiens
-
HEK-293 cell
-
Homo sapiens
-
MCF-7 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information promotes the reversal of cysteine modified PTP1B to its reduced and enzymatically active form Homo sapiens ?
-
?
additional information reduction of cysteine sulfinic acid to sulfenic acid in proteins subject to oxidative stress Homo sapiens ?
-
?
peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + R-SH
-
Homo sapiens peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R
-
?

Synonyms

Synonyms Comment Organism
protein cysteine sulfinic acid reductase
-
Homo sapiens
Srx
-
Homo sapiens
sulfiredoxin
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens oxidative stress and growth factors can markedly upregulate Srx transcript and protein levels up