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Literature summary for 2.1.1.13 extracted from

  • Taylor, R.T.; Weissbach, H.
    N5-Methyltetrahydrofolate-homocysteine methyltransferases (1973), The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ), 12, 121-165.
No PubMed abstract available

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information
-
Escherichia coli
0.0016
-
S-adenosyl-L-methionine
-
Escherichia coli
0.016
-
L-homocysteine
-
Escherichia coli
0.03
-
5-methyltetrahydrofolate
-
Escherichia coli

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Rattus norvegicus 5737
-
mitochondrion
-
Rattus norvegicus 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
140000 150000 gel filtration, sedimentation coefficient in sucrose density gradients Escherichia coli

Organism

Organism UniProt Comment Textmining
Auxenochlorella pyrenoidosa
-
-
-
Bos taurus
-
-
-
Cereibacter sphaeroides
-
-
-
Escherichia coli
-
-
-
Gallus gallus
-
-
-
Homo sapiens
-
-
-
Klebsiella aerogenes
-
-
-
Ochromonas malhamensis
-
-
-
Rattus norvegicus
-
-
-
Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
B Escherichia coli

Reaction

Reaction Comment Organism Reaction ID
5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine mechanism Salmonella enterica subsp. enterica serovar Typhimurium
5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine mechanism Gallus gallus
5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine mechanism Escherichia coli
5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine mechanism Homo sapiens
5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine mechanism Rattus norvegicus
5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine mechanism Sus scrofa
5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine mechanism Bos taurus
5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine mechanism Cereibacter sphaeroides
5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine mechanism Klebsiella aerogenes
5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine mechanism Auxenochlorella pyrenoidosa
5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine mechanism Ochromonas malhamensis

Renatured (Commentary)

Renatured (Comment) Organism
incubation of resolved apoenzyme with methyl-B12 results in spontaneous formation of holoenzyme Escherichia coli

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-
brain
-
Bos taurus
-
kidney
-
Homo sapiens
-
kidney
-
Sus scrofa
-
kidney
-
Bos taurus
-
liver
-
Gallus gallus
-
liver
-
Homo sapiens
-
liver
-
Rattus norvegicus
-
liver
-
Sus scrofa
-
liver
-
Bos taurus
-
tissue culture
-
Homo sapiens
-
tissue culture a variety of mammalian cell lines in tissue culture Rattus norvegicus
-
tissue culture a variety of mammalian cell lines in tissue culture Sus scrofa
-
tissue culture a variety of mammalian cell lines in tissue culture Bos taurus
-
tissue culture a variety of mammalian cell lines in tissue culture Auxenochlorella pyrenoidosa
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Salmonella enterica subsp. enterica serovar Typhimurium
additional information
-
-
Gallus gallus
additional information
-
-
Rattus norvegicus
additional information
-
-
Bos taurus
additional information
-
-
Cereibacter sphaeroides
additional information
-
-
Klebsiella aerogenes
additional information
-
-
Auxenochlorella pyrenoidosa
additional information
-
-
Ochromonas malhamensis
additional information
-
assay method Escherichia coli
additional information
-
assay method Homo sapiens
additional information
-
assay method Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-methyltetrahydrofolate + 2-mercaptoethanol
-
Escherichia coli S-methylmercaptoethanol + tetrahydrofolate
-
?
5-methyltetrahydrofolate + L-homocysteine
-
Escherichia coli tetrahydrofolate + L-methionine
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
-
Salmonella enterica subsp. enterica serovar Typhimurium tetrahydropteroylmonoglutamate + L-methionine
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
-
Gallus gallus tetrahydropteroylmonoglutamate + L-methionine
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
-
Escherichia coli tetrahydropteroylmonoglutamate + L-methionine
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
-
Homo sapiens tetrahydropteroylmonoglutamate + L-methionine
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
-
Rattus norvegicus tetrahydropteroylmonoglutamate + L-methionine
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
-
Sus scrofa tetrahydropteroylmonoglutamate + L-methionine
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
-
Bos taurus tetrahydropteroylmonoglutamate + L-methionine
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
-
Cereibacter sphaeroides tetrahydropteroylmonoglutamate + L-methionine
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
-
Klebsiella aerogenes tetrahydropteroylmonoglutamate + L-methionine
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
-
Auxenochlorella pyrenoidosa tetrahydropteroylmonoglutamate + L-methionine
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
-
Ochromonas malhamensis tetrahydropteroylmonoglutamate + L-methionine
-
?
N5-methyltetrahydropteroyltriglutamate + L-homocysteine
-
Salmonella enterica subsp. enterica serovar Typhimurium tetrahydropteroyltriglutamate + L-methionine
-
?
N5-methyltetrahydropteroyltriglutamate + L-homocysteine
-
Gallus gallus tetrahydropteroyltriglutamate + L-methionine
-
?
N5-methyltetrahydropteroyltriglutamate + L-homocysteine
-
Escherichia coli tetrahydropteroyltriglutamate + L-methionine
-
?
N5-methyltetrahydropteroyltriglutamate + L-homocysteine
-
Homo sapiens tetrahydropteroyltriglutamate + L-methionine
-
?
N5-methyltetrahydropteroyltriglutamate + L-homocysteine
-
Rattus norvegicus tetrahydropteroyltriglutamate + L-methionine
-
?
N5-methyltetrahydropteroyltriglutamate + L-homocysteine
-
Sus scrofa tetrahydropteroyltriglutamate + L-methionine
-
?
N5-methyltetrahydropteroyltriglutamate + L-homocysteine
-
Bos taurus tetrahydropteroyltriglutamate + L-methionine
-
?
N5-methyltetrahydropteroyltriglutamate + L-homocysteine
-
Cereibacter sphaeroides tetrahydropteroyltriglutamate + L-methionine
-
?
N5-methyltetrahydropteroyltriglutamate + L-homocysteine
-
Klebsiella aerogenes tetrahydropteroyltriglutamate + L-methionine
-
?
N5-methyltetrahydropteroyltriglutamate + L-homocysteine
-
Auxenochlorella pyrenoidosa tetrahydropteroyltriglutamate + L-methionine
-
?
N5-methyltetrahydropteroyltriglutamate + L-homocysteine
-
Ochromonas malhamensis tetrahydropteroyltriglutamate + L-methionine
-
?
S-adenosyl-L-methionine + L-homocysteine
-
Escherichia coli methionine + S-adenosyl-L-homocysteine
-
?
S-adenosyl-L-methionine + tetrahydrofolate
-
Escherichia coli 5-methyltetrahydrofolate + S-adenosyl-L-homocysteine
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.0217
-
S-adenosyl-L-methionine
-
Escherichia coli
0.0367
-
S-adenosyl-L-methionine
-
Escherichia coli
8.33 13 5-methyltetrahydrofolate
-
Escherichia coli

Cofactor

Cofactor Comment Organism Structure
additional information absolute requirement for a reducing system Salmonella enterica subsp. enterica serovar Typhimurium
additional information absolute requirement for a reducing system Gallus gallus
additional information absolute requirement for a reducing system Escherichia coli
additional information absolute requirement for a reducing system Homo sapiens
additional information absolute requirement for a reducing system Rattus norvegicus
additional information absolute requirement for a reducing system Sus scrofa
additional information absolute requirement for a reducing system Bos taurus
additional information absolute requirement for a reducing system Cereibacter sphaeroides
additional information absolute requirement for a reducing system Klebsiella aerogenes
additional information absolute requirement for a reducing system Auxenochlorella pyrenoidosa
additional information absolute requirement for a reducing system Ochromonas malhamensis
S-adenosyl-L-methionine required Salmonella enterica subsp. enterica serovar Typhimurium
S-adenosyl-L-methionine required Gallus gallus
S-adenosyl-L-methionine required Escherichia coli
S-adenosyl-L-methionine required Homo sapiens
S-adenosyl-L-methionine required Rattus norvegicus
S-adenosyl-L-methionine required Sus scrofa
S-adenosyl-L-methionine required Bos taurus
S-adenosyl-L-methionine required Cereibacter sphaeroides
S-adenosyl-L-methionine required Klebsiella aerogenes
S-adenosyl-L-methionine required Auxenochlorella pyrenoidosa
S-adenosyl-L-methionine required Ochromonas malhamensis
S-adenosyl-L-methionine role of S-adenosyl-L-methionine Escherichia coli
vitamin B12 enzyme contains a derivative of vitamin B12 as prosthetic group Salmonella enterica subsp. enterica serovar Typhimurium
vitamin B12 enzyme contains a derivative of vitamin B12 as prosthetic group Gallus gallus
vitamin B12 enzyme contains a derivative of vitamin B12 as prosthetic group Escherichia coli
vitamin B12 enzyme contains a derivative of vitamin B12 as prosthetic group Homo sapiens
vitamin B12 enzyme contains a derivative of vitamin B12 as prosthetic group Rattus norvegicus
vitamin B12 enzyme contains a derivative of vitamin B12 as prosthetic group Sus scrofa
vitamin B12 enzyme contains a derivative of vitamin B12 as prosthetic group Bos taurus
vitamin B12 enzyme contains a derivative of vitamin B12 as prosthetic group Cereibacter sphaeroides
vitamin B12 enzyme contains a derivative of vitamin B12 as prosthetic group Klebsiella aerogenes
vitamin B12 enzyme contains a derivative of vitamin B12 as prosthetic group Auxenochlorella pyrenoidosa
vitamin B12 enzyme contains a derivative of vitamin B12 as prosthetic group Ochromonas malhamensis