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Literature summary for 2.1.1.166 extracted from

  • Bügl, H.; Fauman, E.B.; Staker, B.L.; Zheng, F.; Kushner, S.R.; Saper, M.A.; Bardwell, J.C.; Jakob, U.
    RNA methylation under heat shock control (2000), Mol. Cell, 6, 349-360.
    View publication on PubMed
Search for more literature for 2.1.1.166

Cloned(Commentary)

Cloned (Comment) Organism
-
 Escherichia coli

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structure of the FtsJ protein at 1.5 A resolution in complex with its cofactor S-adenosyl-L-methionine Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + uridine2552 in 23S rRNA Escherichia coli in vivo methylation of 23S rRNA by FtsJ goes to near completion S-adenosyl-L-homocysteine + 2'-O-methyluridine2552 in 23S rRNA
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli A0A140N5X9
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + uridine2552 in 23S rRNA
-
 Escherichia coli S-adenosyl-L-homocysteine + 2'-O-methyluridine2552 in 23S rRNA
-
 ?
S-adenosyl-L-methionine + uridine2552 in 23S rRNA in vivo methylation of 23S rRNA by FtsJ goes to near completion Escherichia coli S-adenosyl-L-homocysteine + 2'-O-methyluridine2552 in 23S rRNA
-
 ?

Synonyms

Synonyms Comment Organism
FTSJ
-
 Escherichia coli

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Escherichia coli

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Escherichia coli

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine tightly bound Escherichia coli

General Information

General Information Comment Organism
malfunction null mutations in ftsJ show a dramatically altered ribosome profile, a severe growth disadvantage, and a temperature-sensitive phenotype Escherichia coli