Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.166 extracted from

  • Hwang, J.; Inouye, M.
    Interaction of an essential Escherichia coli GTPase, Der, with the 50S ribosome via the KH-like domain (2010), J. Bacteriol., 192, 2277-2283.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.166

Protein Variants

Protein Variants Comment Organism
additional information generation of a DELTArrmJ deletion strain Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + uridine2552 in 23S rRNA Escherichia coli rrmJ gene encodes a methyltransferase that modifies the U2552 residue of 23S rRNA S-adenosyl-L-homocysteine + 2'-O-methyluridine2552 in 23S rRNA
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
 gene rrmJ
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + uridine2552 in 23S rRNA
-
 Escherichia coli S-adenosyl-L-homocysteine + 2'-O-methyluridine2552 in 23S rRNA
-
 ?
S-adenosyl-L-methionine + uridine2552 in 23S rRNA rrmJ gene encodes a methyltransferase that modifies the U2552 residue of 23S rRNA Escherichia coli S-adenosyl-L-homocysteine + 2'-O-methyluridine2552 in 23S rRNA
-
 ?

Synonyms

Synonyms Comment Organism
RrmJ
-
 Escherichia coli

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
 Escherichia coli

General Information

General Information Comment Organism
malfunction rrmJ gene deletion causes a severe growth defect and accumulation of aberrant 50S ribosomal subunits in DELTArrmJ. Overexpression of GTPase Der suppresses growth impairment, effects of several Der mutants, overview. In a rrmJ deletion strain, two GTPase domains of Der regulate its association with 50S subunit via the KH-like domain. Phenotypes, overview Escherichia coli