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Literature summary for 2.1.1.37 extracted from
- DNA (cytosine-5)-methyltransferases in mouse cells and tissues. Studies with a mechanism-based probe (1997), J. Mol. Biol., 270, 385-395.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | intrinsic sequence-specificity of Dnmt1 on linear duplex DNA is unlikely to be important in the establishment of genomic methylation patterns | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythroleukemia cell | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | intrinsic sequence-specificity of Dnmt1 on linear duplex DNA is unlikely to be important in the establishment of genomic methylation patterns | Mus musculus | ? | - |
? | |
| S-adenosyl-L-methionine + DNA | - |
Mus musculus | S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine | - |
? | |
| S-adenosyl-L-methionine + DNA | specificity is confined to the sequence 5'-CpG-3'. Any sequence-specific de novo methylation mediated by Dnmt1 is either under the control of regulatory factors that interact | Mus musculus | S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine | - |
? | |
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