Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.37 extracted from

  • Guo, Z.; Tsai, M.H.; Shiao, Y.H.; Chen, L.H.; Wei, M.L.; Lv, X.; Gius, D.; Little, J.B.; Mitchell, J.B.; Chuang, E.Y.
    DNA (cytosine-5)-methyltransferase 1 as a mediator of mutant p53-determined p16(ink4A) down-regulation (2008), J. Biomed. Sci., 15, 163-168.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
TK-6 cell B lymphoblast cell line containing wild-type p53. The interaction between p53 and DNMT1 controls DNA methylation of the p16ink4A promoter that consequently reduces the level of the p16ink4A Homo sapiens
-
WTK-1 cell B lymphoblast cell line with mutant p53. Mutant p53 loses its ability to suppress DNMT1 expression, and thus enhances methylation levels of the p16ink4A promoter and subsequently down-regulates p16ink4A protein Homo sapiens
-

Synonyms

Synonyms Comment Organism
DNA (cytosine-5)-methyltransferase 1
-
Homo sapiens
Dnmt1
-
Homo sapiens