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Literature summary for 2.1.1.37 extracted from

  • Ye, F.; Xu, X.C.
    Benzo[a]pyrene diol epoxide suppresses retinoic acid receptor-beta2 expression by recruiting DNA (cytosine-5-)-methyltransferase 3A (2010), Mol. Cancer, 9, 93.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adenocarcinoma cell cell line SKGT4 Homo sapiens
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squamous cell carcinoma cell cell lines TE-3 and TE-12 Homo sapiens
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Synonyms

Synonyms Comment Organism
DNA (cytosine-5-)-methyltransferase 3A
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Homo sapiens
Dnmt3a
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Homo sapiens

General Information

General Information Comment Organism
physiological function BPDE recruits DNMT3A to methylate the RAR-beta2 gene promoter and thus silence its gene expression, which in turn, may contribute to the malignant transformation of esophageal epithelial cells Homo sapiens