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Literature summary for 2.1.1.37 extracted from
- Structure Analysis of Entamoeba histolytica DNMT2 (EhMeth) (2012), PLoS ONE, 7, e38728.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli | Entamoeba histolytica |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| crystal structure of the cytosine-5-methyltransferase EhMeth at a resolution of 2.15 A is presented in complex with its reaction product S-adenosyl-L-homocysteine. In contrast to the human DNMT2 structure, the active site loop (residues 80-100) of EhMeth is well defined and clearly forms an alpha-helix | Entamoeba histolytica |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Entamoeba histolytica | tRNA binding studies show that EhMeth interacts with a RNA substrate only containing 17 nucleotides of the tRNA anticodon stem-loop (including the substrate cytosine C38), but requires a full-length tRNA for stable complex formation | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Entamoeba histolytica | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| DNA + S-adenosyl-L-methionine | - |
Entamoeba histolytica | DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine | - |
? | |
| additional information | tRNA binding studies show that EhMeth interacts with a RNA substrate only containing 17 nucleotides of the tRNA anticodon stem-loop (including the substrate cytosine C38), but requires a full-length tRNA for stable complex formation | Entamoeba histolytica | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Dnmt2 | - |
Entamoeba histolytica |
| EhMeth | - |
Entamoeba histolytica |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| S-adenosyl-L-methionine | - |
Entamoeba histolytica | |
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