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Literature summary for 2.1.1.37 extracted from

  • Zhang, G.; Esteve, P.; Chin, H.; Terragni, J.; Dai, N.; Correa, I.J.; Pradhan, S.
    Small RNA-mediated DNA (cytosine-5) methyltransferase 1 inhibition leads to aberrant DNA methylation (2015), Nucleic Acids Res., 43, 6112-6124 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.37

Activating Compound

Activating Compound Comment Organism Structure
RNAse A RNase A treatment increases DNMT1 activity in vitro. The methyltransferase activity on hemimethylated DNA is about 8fold higher compared to control, and 2fold higher on a poly(dI-dC) substrate Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in Sf9 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
asCEBPA-1 RNA competitive with respect to substrate (CMeGG-CCG)12 Homo sapiens
asCEBPA-2 RNA mixed inhibition Homo sapiens
asCEPA-1HPE RNA competitive with respect to substrate (CMeGG-CCG)12 Homo sapiens
asCEPA-2HPE RNA competitive with respect to substrate (CMeGG-CCG)12 Homo sapiens
miR-127-3p micro-RNA, competitive with respect to substrate (CMeGG-CCG)12 Homo sapiens
miR-145-5p micro-RNA, competitive with respect to substrate (CMeGG-CCG)12 Homo sapiens
miR-146a-5p micro-RNA, competitive with respect to substrate (CMeGG-CCG)12 Homo sapiens
miR-155-5p micro-RNA, competitive with respect to substrate (CMeGG-CCG)12; micro-RNA. Exogenous miR-155-5p in cells inhibits DNMT1 and induces aberrant DNA methylation of the genome Homo sapiens
miR-16-5p micro-RNA, competitive with respect to substrate (CMeGG-CCG)12 Homo sapiens
miR-17-5p micro-RNA, competitive with respect to substrate (CMeGG-CCG)12 Homo sapiens
miR-19b-3p micro-RNA, competitive with respect to substrate (CMeGG-CCG)12 Homo sapiens
miR-20a-5p micro-RNA, competitive with respect to substrate (CMeGG-CCG)12 Homo sapiens
miR-21-5p micro-RNA, competitive with respect to substrate (CMeGG-CCG)12 Homo sapiens
miR-373-5p micro-RNA, competitive with respect to substrate (CMeGG-CCG)12 Homo sapiens
miR-9-3p micro-RNA, competitive with respect to substrate (CMeGG-CCG)12 Homo sapiens
miR-9-5p micro-RNA, competitive with respect to substrate (CMeGG-CCG)12 Homo sapiens
miR-92-1-5p micro-RNA, competitive with respect to substrate (CMeGG-CCG)12 Homo sapiens
miR-92a-1-5p micro-RNA, competitive with respect to substrate (CMeGG-CCG)12 Homo sapiens
miR-92a-3p micro-RNA, competitive with respect to substrate (CMeGG-CCG)12 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P26358
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + (CMeGG-CCG)12
-
 Homo sapiens S-adenosyl-L-homocysteine + (CMeGG-CCG)12 containing 5-methylcytosine
-
 ?
S-adenosyl-L-methionine + poly (dI-dC)
-
 Homo sapiens S-adenosyl-L-homocysteine + poly (dI-dC) containing 5-methylcytosine
-
 ?

Synonyms

Synonyms Comment Organism
Dnmt1
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000028
-
 miR-155-5p substrate (CMeGG-CCG)12, pH 8.0, 37°C Homo sapiens
0.00009
-
 asCEBPA-2 RNA substrate (CMeGG-CCG)12, pH 8.0, 37°C Homo sapiens
0.000135
-
 asCEPA-2HPE RNA substrate (CMeGG-CCG)12, pH 8.0, 37°C Homo sapiens
0.000269
-
 miR-127-3p substrate (CMeGG-CCG)12, pH 8.0, 37°C Homo sapiens
0.000298
-
 miR-373-5p substrate (CMeGG-CCG)12, pH 8.0, 37°C Homo sapiens
0.000317
-
 miR-17-5p substrate (CMeGG-CCG)12, pH 8.0, 37°C Homo sapiens
0.00043
-
 asCEBPA-2 RNA substrate S-adenosyl-L-methionine, pH 8.0, 37°C Homo sapiens
0.000463
-
 miR-16-5p substrate (CMeGG-CCG)12, pH 8.0, 37°C Homo sapiens
0.000476
-
 miR-92a-1-5p substrate (CMeGG-CCG)12, pH 8.0, 37°C Homo sapiens
0.000493
-
 miR-9-5p substrate (CMeGG-CCG)12, pH 8.0, 37°C Homo sapiens
0.000561
-
 miR-20a-5p substrate (CMeGG-CCG)12, pH 8.0, 37°C Homo sapiens
0.00092
-
 asCEPA-1HPE RNA substrate (CMeGG-CCG)12, pH 8.0, 37°C Homo sapiens
0.001031
-
 miR-146a-5p substrate (CMeGG-CCG)12, pH 8.0, 37°C Homo sapiens
0.001291
-
 miR-21-5p substrate (CMeGG-CCG)12, pH 8.0, 37°C Homo sapiens
0.001602
-
 miR-9-3p substrate (CMeGG-CCG)12, pH 8.0, 37°C Homo sapiens
0.00165
-
 miR-92a-3p substrate (CMeGG-CCG)12, pH 8.0, 37°C Homo sapiens
0.002
-
 asCEBPA-1 RNA substrate (CMeGG-CCG)12, pH 8.0, 37°C Homo sapiens
0.002458
-
 miR-145-5p substrate (CMeGG-CCG)12, pH 8.0, 37°C Homo sapiens
0.003323
-
 miR-19b-3p substrate (CMeGG-CCG)12, pH 8.0, 37°C Homo sapiens

General Information

General Information Comment Organism
physiological function endogenous DNMT1 copurifies with inhibitory ncRNAs. miRNAs bind directly to DNMT1 with high affinity, leading to inhibition of DNMT1 enzyme activity. Exogenous miR-155-5p in cells induces aberrant DNA methylation of the genome Homo sapiens