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Literature summary for 2.1.1.45 extracted from

  • Capco, G.R.; Krupp, J.R.; Mathews, C.K.
    Bacteriophage-coded thymidylate synthetase: characteristics of the T4 and T5 enzymes (1973), Arch. Biochem. Biophys., 158, 726-735.
    View publication on PubMed

General Stability

General Stability Organism
quite unstable Tequatrovirus T4
quite unstable Tequintavirus T5

Inhibitors

Inhibitors Comment Organism Structure
5-fluoro-2'-deoxyuridylic acid
-
Lacticaseibacillus casei
5-fluoro-2'-deoxyuridylic acid
-
Tequatrovirus T4
trifluoromethyldeoxyuridine 5'-monophosphate
-
Tequatrovirus T4

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
29000
-
2 * 29000, SDS-PAGE Tequatrovirus T4
55000
-
gel filtration Tequintavirus T5
58000
-
sucrose density gradient analysis Tequatrovirus T4

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5,10-methylenetetrahydrofolate + dUMP Lacticaseibacillus casei
-
dihydrofolate + dTMP
-
?
5,10-methylenetetrahydrofolate + dUMP Tequatrovirus T4
-
dihydrofolate + dTMP
-
?
5,10-methylenetetrahydrofolate + dUMP Tequintavirus T5
-
dihydrofolate + dTMP
-
?

Organism

Organism UniProt Comment Textmining
Lacticaseibacillus casei
-
-
-
Tequatrovirus T4
-
-
-
Tequintavirus T5
-
-
-

Purification (Commentary)

Purification (Comment) Organism
purified from phage infected E. coli Tequatrovirus T4
purified from phage infected E. coli Tequintavirus T5

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
14.2
-
-
Tequintavirus T5
14.45
-
-
Tequatrovirus T4

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,10-methylenetetrahydrofolate + dUMP
-
Lacticaseibacillus casei dihydrofolate + dTMP
-
?
5,10-methylenetetrahydrofolate + dUMP
-
Lacticaseibacillus casei dihydrofolate + dTMP
-
r
5,10-methylenetetrahydrofolate + dUMP
-
Tequatrovirus T4 dihydrofolate + dTMP
-
?
5,10-methylenetetrahydrofolate + dUMP
-
Tequatrovirus T4 dihydrofolate + dTMP
-
r
5,10-methylenetetrahydrofolate + dUMP
-
Tequintavirus T5 dihydrofolate + dTMP
-
?
5,10-methylenetetrahydrofolate + dUMP
-
Tequintavirus T5 dihydrofolate + dTMP
-
r

Subunits

Subunits Comment Organism
dimer
-
Lacticaseibacillus casei
dimer 2 * 29000, SDS-PAGE Tequatrovirus T4