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Literature summary for 2.1.1.45 extracted from

  • Sienkiewicz, N.; Jaros?awski, S.; Wyllie, S.; Fairlamb, A.H.
    Chemical and genetic validation of dihydrofolate reductase-thymidylate synthase as a drug target in African trypanosomes (2008), Mol. Microbiol., 69, 520-533.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.45

Inhibitors

Inhibitors Comment Organism Structure
2'-deoxy-5-fluorouridine 5'-phosphate
-
 Trypanosoma brucei
pemetrexed
-
 Trypanosoma brucei
raltitrexed
-
 Trypanosoma brucei

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,10-methylenetetrahydrofolate + dUMP
-
 Trypanosoma brucei dihydrofolate + dTMP
-
 ?

Synonyms

Synonyms Comment Organism
DHFR–TS
-
 Trypanosoma brucei
dihydrofolate reductase-thymidylate synthase bifunctional enzyme Trypanosoma brucei

Cofactor

Cofactor Comment Organism Structure
N5,N10-methylenetetrahydrofolate
-
 Trypanosoma brucei

General Information

General Information Comment Organism
malfunction growth of single-knockout lines of dihydrofolate reductase-thymidylate synthase in vitro are identical to wild type cells, whereas double-knockout lines of dihydrofolate reductase-thymidylate synthase have an absolute requirement for thymidine Trypanosoma brucei
physiological function DHFR–TS is essential for parasite survival Trypanosoma brucei