Inhibitors | Comment | Organism | Structure |
---|---|---|---|
methotrexate | - |
Escherichia coli | |
methotrexate | - |
Homo sapiens | |
methotrexate | - |
Toxoplasma gondii | |
N-[4-[(2,4-diamino-5-methyl-furo[2,3-d]pyrimidin-6-yl)thio]-benzoyl]-L-glutamic acid | - |
Escherichia coli | |
N-[4-[(2,4-diamino-5-methyl-furo[2,3-d]pyrimidin-6-yl)thio]-benzoyl]-L-glutamic acid | - |
Homo sapiens | |
N-[4-[(2,4-diamino-5-methyl-furo[2,3-d]pyrimidin-6-yl)thio]-benzoyl]-L-glutamic acid | - |
Toxoplasma gondii | |
pemetrexed | - |
Escherichia coli | |
pemetrexed | - |
Homo sapiens | |
pemetrexed | - |
Toxoplasma gondii | |
raltitrexed | - |
Escherichia coli | |
raltitrexed | - |
Homo sapiens | |
raltitrexed | - |
Toxoplasma gondii | |
trimethoprim | - |
Escherichia coli | |
trimethoprim | - |
Homo sapiens | |
trimethoprim | - |
Toxoplasma gondii | |
trimetrexate | - |
Escherichia coli | |
trimetrexate | - |
Homo sapiens | |
trimetrexate | - |
Toxoplasma gondii |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Homo sapiens | - |
- |
- |
Toxoplasma gondii | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,10-methylenetetrahydrofolate + dUMP | - |
Escherichia coli | dihydrofolate + dTMP | - |
? | |
5,10-methylenetetrahydrofolate + dUMP | - |
Homo sapiens | dihydrofolate + dTMP | - |
? | |
5,10-methylenetetrahydrofolate + dUMP | - |
Toxoplasma gondii | dihydrofolate + dTMP | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00038 | - |
at 30°C and pH 7.4 | Homo sapiens | raltitrexed | |
0.0009 | - |
at 30°C and pH 7.4 | Toxoplasma gondii | raltitrexed | |
0.0028 | - |
at 30°C and pH 7.4 | Toxoplasma gondii | pemetrexed | |
0.0054 | - |
at 30°C and pH 7.4 | Homo sapiens | N-[4-[(2,4-diamino-5-methyl-furo[2,3-d]pyrimidin-6-yl)thio]-benzoyl]-L-glutamic acid | |
0.0057 | - |
at 30°C and pH 7.4 | Escherichia coli | raltitrexed | |
0.0095 | - |
at 30°C and pH 7.4 | Homo sapiens | pemetrexed | |
0.018 | - |
at 30°C and pH 7.4 | Toxoplasma gondii | methotrexate | |
0.027 | - |
at 30°C and pH 7.4 | Toxoplasma gondii | N-[4-[(2,4-diamino-5-methyl-furo[2,3-d]pyrimidin-6-yl)thio]-benzoyl]-L-glutamic acid | |
0.029 | - |
at 30°C and pH 7.4 | Homo sapiens | methotrexate | |
0.076 | - |
at 30°C and pH 7.4 | Escherichia coli | pemetrexed | |
0.09 | - |
at 30°C and pH 7.4 | Escherichia coli | methotrexate | |
0.23 | - |
at 30°C and pH 7.4 | Escherichia coli | N-[4-[(2,4-diamino-5-methyl-furo[2,3-d]pyrimidin-6-yl)thio]-benzoyl]-L-glutamic acid |