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Literature summary for 2.1.1.50 extracted from
- S-Adenosyl-L-methionine: loganic acid methyltransferase. A carboxyl-alkylating enzyme from Vinca rosea (1973), J. Biol. Chem., 248, 2497-2501.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| iodoacetamide | - |
Catharanthus roseus |  |
| KCN | - |
Catharanthus roseus | |
| N-Methylmaleimide | - |
Catharanthus roseus | |
| p-chloromercuribenzoate | - |
Catharanthus roseus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 12.5 | - |
loganic acid | - |
Catharanthus roseus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| additional information | dependency on divalent metal cations not detected | Catharanthus roseus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + loganate | Catharanthus roseus | biosynthesis of indole alkaloids | S-adenosyl-L-homocysteine + loganin | - |
? | |
| S-adenosyl-L-methionine + secologanate | Catharanthus roseus | - |
S-adenosyl-L-homocysteine + secologanin | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Catharanthus roseus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Catharanthus roseus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | no significant methylation of: 7-deoxyloganic acid, geniposidic acid, 7-epiloganic acid | Catharanthus roseus | ? | - |
? | |
| S-adenosyl-L-methionine + loganate | - |
Catharanthus roseus | S-adenosyl-L-homocysteine + loganin | - |
? | |
| S-adenosyl-L-methionine + loganate | biosynthesis of indole alkaloids | Catharanthus roseus | S-adenosyl-L-homocysteine + loganin | - |
? | |
| S-adenosyl-L-methionine + secologanate | - |
Catharanthus roseus | S-adenosyl-L-homocysteine + secologanin | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 32 | 33 | assay at | Catharanthus roseus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.2 | - |
assay at | Catharanthus roseus |
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Release 2023.1 (January 2023)
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