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Literature summary for 2.1.1.63 extracted from

  • Kreklau, E.L.; Liu, N.; Li, Z.; Cornetta, K.; Erickson, L.C.
    Comparison of single- versus double-bolus treatments of O6-benzylguanine for depletion of O6-methylguanine DNA methyltransferase (MGMT) activity in vivo: development of a novel fluorometric oligonucleotide assay for measurement of MGMT activity (2001), J. Pharmacol. Exp. Ther., 297, 524-530.
    View publication on PubMed
Search for more literature for 2.1.1.63

Application

Application Comment Organism
medicine the efficiacy of 6-O-benzylguanine as a chemomodulator depends on the extent of depletion of 6-O-methylguanine DNA methyltransferase in normal tissues and the optimal therapeutic index for combination of 6-O-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea therapy should be achieved by depleting 6-O-methylguanine DNA methyltransferase in the target tumor for 24 h with minimal depletion in normal tissues Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bone marrow
-
 Homo sapiens
-
brain
-
 Homo sapiens
-
kidney
-
 Homo sapiens
-
liver
-
 Homo sapiens
-
lung
-
 Homo sapiens
-
spleen
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 developmemt of a novel fluorometric oligonucleotide assay to measure enzyme activity in cellular and tissue extracts Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA containing 6-O-methylguanine + [protein]-L-cysteine
-
 Homo sapiens DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
-
 ?