Literature summary for 2.1.1.63 extracted from

Geoerger, B.; Vassal, G.; Doz, F.; OQuigley, J.; Wartelle, M.; Watson, A.J.; Raquin, M.A.; Frappaz, D.; Chastagner, P.; Gentet, J.C.; Rubie, H.; Couanet, D.; Geoffray, A.; Djafari, L.; Margison, G.P.; Pein, F.
Dose finding and O6-alkylguanine-DNA alkyltransferase study of cisplatin combined with temozolomide in paediatric solid malignancies (2005), Br. J. Cancer, 93, 529-537.

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Application

Application	Comment	Organism
medicine	combining cisplatin and temozolomide is based on the potential for improved antitumour activity, combination is well tolerated in children and adolescents, generating no toxicity greater than that of the single agents	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
temozolomide	treatment for 5 days depletes MGMT in peripheral mononuclear cells in at least 76% of patients and low MGMT activity is correlated with severe thrombocytopenia during the first treatment cycle	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
PBMC cell line	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
DNA containing 6-O-methylguanine + [protein]-L-cysteine	-	Homo sapiens	DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine	-	?

Synonyms

Synonyms	Comment	Organism
MGMT	-	Homo sapiens
O6-alkylguanine-DNA alkyltransferase	-	Homo sapiens

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Release 2023.1 (January 2023)