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Literature summary for 2.1.1.63 extracted from

  • Rasimas, J.J.; Kar, S.R.; Pegg, A.E.; Fried, M.G.
    Interactions of human O6-alkylguanine-DNA alkyltransferase (AGT) with short single-stranded DNAs (2007), J. Biol. Chem., 282, 3357-3366.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.63

Application

Application Comment Organism
molecular biology modest binding cooperativity and high binding densities of AGT are adaptations that allow the enzyme to efficiently search for lesions in the context of chromatin remodeling and DNA replication Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
21614
-
 x * 21860, SDS-PAGE, x * 21614, sequence analysis Homo sapiens
21860
-
 x * 21860, SDS-PAGE, x * 21614, sequence analysis Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P16455
-
-

Purification (Commentary)

Purification (Comment) Organism
to apparent homogeneity Homo sapiens

Storage Stability

Storage Stability Organism
-80°C Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information binding of AGT to single-stranded DNAs ranging in length from 5 to 78 nucleotides, binding is moderately cooperative, resulting in an all-or-nothing association pattern on short templates binding density Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 21860, SDS-PAGE, x * 21614, sequence analysis Homo sapiens

Synonyms

Synonyms Comment Organism
AGT
-
 Homo sapiens
O6-alkylguanine-DNA alkyltransferase
-
 Homo sapiens